Endocrine function of the kidneys 0.0 / 5 ? PharmacyThe KidneysUniversityNone Created by: SamDaviesCreated on: 11-04-19 18:27 What is the function of erythropoietin? Controls RBC production (erythropoiesis) by the bone marrow? 1 of 17 Where is fetal erythropoetin made? Liver 2 of 17 Where is adult erythropoietin made? Kidneys 3 of 17 How is hypoxia detected? Hypoxia inducible transcription factors (HIF) 4 of 17 HIF-1 alpha is constitutively expressed. True or false? True 5 of 17 With normal oxygen levels, hydroxylation of proline (found on HIF-1 alpha) leads to proteasomal degradation. True or false? True 6 of 17 With normal levels of oxygen, HIF-1 alpha forms a complex with HIF-1 beta and hypoxia response elements. True or false? False 7 of 17 Is the erythropoietin receptor homodimeric or heterodimeric? Homodimeric 8 of 17 Where is the erythropoetin receptor found? Red cell precursors in the bone marrow 9 of 17 What kind of feedback does EPO have on the RAAS system? Negative feedback 10 of 17 What is the treatment for renal anaemia? Recombinant erythropoietin 11 of 17 The first stage of vitamin D production is the UV-dependent photolysis of ----- to -----. 7-dehydrocholesterol, cholecalciferol 12 of 17 Where in the body is cholecalciferol converted to 25(OH)2D3? Liver 13 of 17 The conversion of cholecalciferol to 25(OH)2D3 is a constitutive process. True or false? True 14 of 17 What is the name of the receptor on the PCT epithelial lumen which picks up the 25(OH)2D3/DBP complex? Megalin 15 of 17 Where is 25(OH)2D3 hydroxylated into 1,25(OH)2D3? Mitochondria 16 of 17 What substance is produced by the inactivation of active vitamin D by the enzyme 24-hydroxylase? Calcitroic acid 17 of 17
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