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What is humoral immunity?
Many pathogens multiply in extracellular space - this space is protected by humoral immune system - antibodies produced by activated B cells - bind and kill pathogen
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What are B cells?
Type of antigen presenting cell (APC) - present matched antigens to Th2 cells
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How do B cells present antigen?
Express specific receptors for foreign antigens (engulf & express) - antigen is internalised by endocytosis - antigen derived proteins then selectively presented on B cell surface
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How do T and B cells interact?
Helper T cells interact with B cells via an antigen bridge - B cells bind to one determinant on antigen molecule while T cells recognises another determinant (a carrier) - linked recognition - both B and T have been exposed to same antigen
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What is the Th2 response?
T and B interactions lead to antigen recognition - cytokines produced - T helper cytokines dictate type of antibody produced -
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What are plasma cells?
B cells (WBCs)
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What are antibodies?
Y shaped proteins - secreted by plasma cells - expressed on B cell surface - prevent pathogenic adherence - promote phagocytosis -
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What is opsonisation?
Pathogen marking - for ingestion by macrophage - antibodies can bind to Fc receptors
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What is neutralisation?
Toxins bind to cell receptor - release causing cell poisoning. Antibodies block binding to virus receptor - IgA and IgG antibodies
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Card 2

Front

What are B cells?

Back

Type of antigen presenting cell (APC) - present matched antigens to Th2 cells

Card 3

Front

How do B cells present antigen?

Back

Preview of the front of card 3

Card 4

Front

How do T and B cells interact?

Back

Preview of the front of card 4

Card 5

Front

What is the Th2 response?

Back

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