ECM

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  • Created by: Sarah
  • Created on: 03-05-17 08:59
why is hyaluronic acid different from other GAGs?
is non sulphated, forms on plasma M
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what does hyaluronic acid do?
roles in cell proliferation, migration and progression of malignant tumours
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how many variants of collagen are there?
20-40
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what is collagen made of?
3 alpha helices
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what is Marfans syndrome? caused by? what gene?
long limbs, heart defects, disorder of elastin CT, mutation in FBN1 gene
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what is the MW of hyaluronic acid?
8 million
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what is ehlers danlos syndrome?
problem in synthesis of collagen causes stretchy skin, has vascular form, prone to arterial rupture
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roles of ECM?
migration, proliferation, tissue integrity+shape, microbe defence, tissue engineering scaffold, differentation
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what is the ECM?
a meshwork of proteins and hydrated macromolecules
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what are the fibrous proteins in ECM?
collagen and elastin
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what are the adhesion proteins in ECM?
laminin and fibronecin
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what are proteoglycans?
GAGS + amino acids
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whats another role of collagen apart from CT?what makes this collagen?
wound healing, fibroblasts make tense collagen
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what can you get from a lack of vitamin c, as vitamin c is needed for collagen syntheisis?
scurvy
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where is elastic fibres and fibrils found?
lung, ligament and blood vessels
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what converts tropoelastin to elastin?
lysyl oxidase
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what combines with elastin to form fibres?
fibrillin
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how long are the sugar disaccharide chains?
70-200
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what is an example of a GAG?
dermatan sulphate, hyaluronic acid
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main roles of proteoglycans?
cushioning (bind water+expand, cartilage, tendon), packing empty spaces in embroygenesis by hyaluronidase, filtering, signal binding on cell surface or extracellular
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what does hyaluronidase do?
creates gaps when things are made for migration
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what is the RGD sequence?
for adhesion glycoproteins like fibronectin recognition
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what does fibronectin bind to?
cells and collagen
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what does laminin do?
axon promoting
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what are integrins?
receptors in the ECM
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what do integrins do?
link ECM and cytoskeleton
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what is glanzmanns thrombosthenia?
problem with integrin so platelets can't aggregat, bleeding disorder
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what is the RGD sequence made up of?
Argenine,aspartimine and glycine
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where is laminin?
in basal laminae
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what are integrins important for in cell migration?
focal adhesions
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Card 2

Front

what does hyaluronic acid do?

Back

roles in cell proliferation, migration and progression of malignant tumours

Card 3

Front

how many variants of collagen are there?

Back

Preview of the front of card 3

Card 4

Front

what is collagen made of?

Back

Preview of the front of card 4

Card 5

Front

what is Marfans syndrome? caused by? what gene?

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