a meshwork of proteins and hydrated macromolecules
9 of 30
what are the fibrous proteins in ECM?
collagen and elastin
10 of 30
what are the adhesion proteins in ECM?
laminin and fibronecin
11 of 30
what are proteoglycans?
GAGS + amino acids
12 of 30
whats another role of collagen apart from CT?what makes this collagen?
wound healing, fibroblasts make tense collagen
13 of 30
what can you get from a lack of vitamin c, as vitamin c is needed for collagen syntheisis?
scurvy
14 of 30
where is elastic fibres and fibrils found?
lung, ligament and blood vessels
15 of 30
what converts tropoelastin to elastin?
lysyl oxidase
16 of 30
what combines with elastin to form fibres?
fibrillin
17 of 30
how long are the sugar disaccharide chains?
70-200
18 of 30
what is an example of a GAG?
dermatan sulphate, hyaluronic acid
19 of 30
main roles of proteoglycans?
cushioning (bind water+expand, cartilage, tendon), packing empty spaces in embroygenesis by hyaluronidase, filtering, signal binding on cell surface or extracellular
20 of 30
what does hyaluronidase do?
creates gaps when things are made for migration
21 of 30
what is the RGD sequence?
for adhesion glycoproteins like fibronectin recognition
22 of 30
what does fibronectin bind to?
cells and collagen
23 of 30
what does laminin do?
axon promoting
24 of 30
what are integrins?
receptors in the ECM
25 of 30
what do integrins do?
link ECM and cytoskeleton
26 of 30
what is glanzmanns thrombosthenia?
problem with integrin so platelets can't aggregat, bleeding disorder
27 of 30
what is the RGD sequence made up of?
Argenine,aspartimine and glycine
28 of 30
where is laminin?
in basal laminae
29 of 30
what are integrins important for in cell migration?
focal adhesions
30 of 30
Other cards in this set
Card 2
Front
what does hyaluronic acid do?
Back
roles in cell proliferation, migration and progression of malignant tumours
Comments
No comments have yet been made