duiretics

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  • Created by: hadar
  • Created on: 20-11-15 22:21
Frusemide (loop)- mechanism of action
inhibits water reabsorption in the nephron by blocking the sodium-potassium-chloride cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. competitive inhibition at the chloride binding site on the cotransporter,
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Frusemide (loop)- therapeutic affect
increase urine production reducing sodium reabsorption therefore reducing water reabsorption
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Bendroflumethiazide (thiazide)- mechanism of action
inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter,
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Bendroflumethiazide (thiazide)- therapeutic affect
inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT). Water is lost as a result of more sodium reaching the collecting ducts. increase in the excretion of sodium, chloride, and water.
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Spironololactone (K sparing) - mechanism of action
antagonist of aldosterone, competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule.
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Spironololactone (K sparing) - therapeutic affect
causes increased amounts of sodium and water to be excreted, while potassium is retained.
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Tamsulosin- mechanism of action
selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck.
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Tamsulosin- therapeutic affect
relaxing bladder neck muscles and muscle fibers in the prostate, Binding receptors → reduces cAMP → decreases influx calcium → muscle relaxation
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Tiotropium- machines of action
muscarinic receptor antagonist, - M3 muscarinic acetylcholine receptors located in the airways to produce smooth muscle
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Tiotropium- therapeutic affect
inhibition of M3–receptors at the smooth muscle leading to bronchodilation. - acetylecholine cant bind → decrease cAMP → decrease calcium in cell → bronchodilation
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Other cards in this set

Card 2

Front

increase urine production reducing sodium reabsorption therefore reducing water reabsorption

Back

Frusemide (loop)- therapeutic affect

Card 3

Front

inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter,

Back

Preview of the back of card 3

Card 4

Front

inhibiting sodium reabsorption at the beginning of the distal convoluted tubule (DCT). Water is lost as a result of more sodium reaching the collecting ducts. increase in the excretion of sodium, chloride, and water.

Back

Preview of the back of card 4

Card 5

Front

antagonist of aldosterone, competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tubule.

Back

Preview of the back of card 5
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