Drugs effecting the PNS

Describe the process of cholinergic neurotransmission
1. Synthesis-Choline+AcCoA--> ACh +CoA in cytoplasm of cholinergic nerves by choline acetyl transferase (CAT)
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Storage
2.Ach taken up into vesicles. Carrier-mediated process-exocytosis (if nerve is stimulated)
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Release
3.Release Ach into synapse presynaptic receptors carmodulate.
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Receptor interaction
Receptor interaction - no specialisation (not like neurone-motor junction)
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Inactivation
Inactivation -(then reuptake) acetylcholinesterases (attached to basal membrane of NMJ) or soluble in CSF turn ACh-->choline and acetate. Enzyme has two binding sites. esteratic site and anionic site (binds choline and N+group)
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What does hemicholiniums do?
Blocks choline uptake so prevents Ach synthesis
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What does Vesamicol do?
Prevents ACh going into vesicles
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What does bo-tox do?
prevent exocytosis of Ach.
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What doe anti-cholinesterases do?
prevent break down of ACh so prolonged effects. Edropgonium-diagnosis of myasthenia gravis. Neostigmine-treatment of it. Ecothipate-treatment of glucoma
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Muscarinic agonists
pilocaprine-glaucoma. bethanechol-gut motility. they both mimic effects of Ach,
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Nicotinic agonists
Saxemrthonium-depolarisation activates but prevents repolarisation so inhibitory. `Used as muscle relaxtant durign surgery
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Nicotnic antagonist
releaxtant during surgery. hexamethonium and trimetaphan.
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Muscarinic antagonists
atropine, hyoscine, ipathropium, tolterodine.
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Card 2

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Storage

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2.Ach taken up into vesicles. Carrier-mediated process-exocytosis (if nerve is stimulated)

Card 3

Front

Release

Back

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Card 4

Front

Receptor interaction

Back

Preview of the front of card 4

Card 5

Front

Inactivation

Back

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