Drug Therapy - Depression

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  • Created by: Amy
  • Created on: 13-06-13 15:00
what is the most common form of treatment for depression?
drug therapy
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when were effective drugs rapidly developed?
1960s
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what are the three main groups of antidepressant drugs?
tricyclics, MAOIs (monoamine-oxidase inhibitors) and SSRIs (selective serotonin re uptake inhibitors)
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how do MAOIs work?
by blocking the enzyme that deactivates noradrenaline and serotonin
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how effective are they?
they worked by elevating the patients' mood, but less effective than tricyclics, 50% success rate
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how appropriate are they?
they have side effects such as raised blood pressure and cerebral haemorrhage caused by eating dairy
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how to tricyclics work?
they block the re-uptake of noradrenaline and serotonin by the neurons that released them
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how effective are they?
effective for mild/severe depression, first choice of treatment, 60-65% of people who take it experience improvement in symptoms, many side effects on cardiovascular system, replaces by modified tricyclics
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how appropriate are they?.
lethal when overdosed therefore dangerous to suicidal people, effective only after 2-3 weeks - delay makes it difficult for them to keep taking it, 50% of users relapse if they stop taking the drug prematurely
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how do SSRIs work?
blocking the reuptake of serotonin
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how effective are they?
most prescribed - 38 mill take it, less side effects that tricyclics, impossible to kill yourself with them - appropriate for suicidal people, some types are banned in the UK
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how appropriate are they?
disturbing accounts of violence and suicide, 250k attempt suicide, 25k succeed, triggers strange agitated mind, impaired sexual functions
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what are some good points of general drug therapy?
quicker than talk therapies, cheaper than most methods, more familiar and less stigma, effective when compared to placebos, suggesting biology does play a role
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how effective are drugs?
treats the symptoms, not the underlying cause; not 100% effective - biology not the only cause and treatment; people often relapse - not permenant
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when were effective drugs rapidly developed?

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1960s

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what are the three main groups of antidepressant drugs?

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how do MAOIs work?

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how effective are they?

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