Drug treatment of cardiovascular disease

Created by: sophieridge
Created on: 15-05-18 13:42

What is atherosclerosis?

A disease in the coronary arteries that can lead to angina/thrombosis. due to a build up of cholesterol rich plaques causing narrowing of the arteries. The fibroys cap holding plaque is thin and can expose cholesterol to the blood.

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How does atherosclerosis start?

starts as a fatty streak that takes up LDL.

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What is cornoary collaterals?

coronary arteries which branch and can give blood to areas of the heart which can reduce effects and slow it down.

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What else can you do?

Give drugs that dilate cornoary arteries and reduce work load. or surgically open up arteries using a catheter. called PCI.

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Main sites of drugs to treat stable angina?

B-blockers, ivabradine - heart. Ca 2+channel blockers. Nicorandil- arteries. Organic nitrates-veins.

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Treatment of myocardial infarction

Perfrom PCI. USe thrombolytic drugs (alteplase) breaks down fibrin network in blood clot. Antiplatelet durgs aspirin-inhibits COX that produces pro-aggregatory factor. and tricagrelor inhibis binding of this to platelets.

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Chronic heart failure

Lower CO so Lower renal perfusion Renal-antigotensin to restore blood volume. These mechanism become long term in heart failure and lead to fibrous cells which worsen heart failure.

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How can you help?

ACE inhibitors to prevent RAA system. B-blockers decrease SNS. aldoeterone antagonist (slow remodelling) valsarta/sacubatril-breakdown vasodilating peptides.

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Hypertension.

140/100 + bp. Diuresis to control blood volume and vasodilation to lower resistance = lower BP.

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Other cards in this set

Card 2

Front

How does atherosclerosis start?

Back

starts as a fatty streak that takes up LDL.

Card 3

Front

What is cornoary collaterals?

Back

Card 4

Front

What else can you do?

Back

Card 5

Front

Main sites of drugs to treat stable angina?

Back

View more cards

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Drug treatment of cardiovascular disease