Drug treatment of cardiovascular disease

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What is atherosclerosis?
A disease in the coronary arteries that can lead to angina/thrombosis. due to a build up of cholesterol rich plaques causing narrowing of the arteries. The fibroys cap holding plaque is thin and can expose cholesterol to the blood.
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How does atherosclerosis start?
starts as a fatty streak that takes up LDL.
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What is cornoary collaterals?
coronary arteries which branch and can give blood to areas of the heart which can reduce effects and slow it down.
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What else can you do?
Give drugs that dilate cornoary arteries and reduce work load. or surgically open up arteries using a catheter. called PCI.
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Main sites of drugs to treat stable angina?
B-blockers, ivabradine - heart. Ca 2+channel blockers. Nicorandil- arteries. Organic nitrates-veins.
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Treatment of myocardial infarction
Perfrom PCI. USe thrombolytic drugs (alteplase) breaks down fibrin network in blood clot. Antiplatelet durgs aspirin-inhibits COX that produces pro-aggregatory factor. and tricagrelor inhibis binding of this to platelets.
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Chronic heart failure
Lower CO so Lower renal perfusion Renal-antigotensin to restore blood volume. These mechanism become long term in heart failure and lead to fibrous cells which worsen heart failure.
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How can you help?
ACE inhibitors to prevent RAA system. B-blockers decrease SNS. aldoeterone antagonist (slow remodelling) valsarta/sacubatril-breakdown vasodilating peptides.
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Hypertension.
140/100 + bp. Diuresis to control blood volume and vasodilation to lower resistance = lower BP.
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Card 2

Front

How does atherosclerosis start?

Back

starts as a fatty streak that takes up LDL.

Card 3

Front

What is cornoary collaterals?

Back

Preview of the front of card 3

Card 4

Front

What else can you do?

Back

Preview of the front of card 4

Card 5

Front

Main sites of drugs to treat stable angina?

Back

Preview of the front of card 5
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