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6. What chromatin modifcation is mediated by ATM/ATR/ DNA-PKcs

  • ADP-ribosylation of H1 and H2B
  • S139 on H2AX for 1-2 MB around DSB
  • Phosphorlyation of HP1

7. MMR is recognised by a

  • Mis match/ insertion / deletion loop which triggers a single stranding insertion
  • glycosylase what removed the bases
  • base adducts that cause helix distortions

8. What is ATR recruited along side

  • AIPRT
  • ATRIP
  • ATPI

9. Alkylating agents repaired by

  • mainly BER but also NER
  • mainly direct reversal and also BER
  • mainly NER but also BER

10. BCRA mediates

  • HR
  • NHEJ

11. DNA topoisomerase drug

  • Doxorubicin
  • cisplatin
  • cyclophosphamide

12. What does Ku activate

  • both
  • DNA-PKcs
  • ATR
  • ATM

13. DNA cross linking agent drug

  • cyclophosphamide
  • cisplatin
  • doxorubicin

14. What chromatin modifcation is mediated by PARP1/2

  • ADP-ribosylation of H1 and H2B
  • Phosphorlyation of HP1
  • S139 on H2AX for 1-2 MB around DSB

15. What is phosphorylated by DNA-PKcs

  • KU
  • itself and activation of recruiting proteins
  • ATR
  • ATM

16. Oxidative DNA damage causes

  • torsional stress
  • base and sugar-phosphate damage and strand breaks
  • base tautormisation
  • base deamination

17. MHEJ stands for

  • Micro-homology- mediated End joining
  • NHEJ
  • HR

18. NER diseases

  • XP and CT
  • XP and CS
  • XP and CS
  • XT and CS

19. what causes helix distortions and impairs DNA transcription and replication

  • base tautomerisation
  • UV damage - DNA base adducts
  • base deamination

20. What kinases do ATM/ATR activate

  • Chk1 and Chk2
  • P53
  • HP1