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6. What chromatin modifcation is mediated by ATM/ATR/ DNA-PKcs
- ADP-ribosylation of H1 and H2B
- S139 on H2AX for 1-2 MB around DSB
- Phosphorlyation of HP1
7. MMR is recognised by a
- Mis match/ insertion / deletion loop which triggers a single stranding insertion
- glycosylase what removed the bases
- base adducts that cause helix distortions
8. What is ATR recruited along side
9. Alkylating agents repaired by
- mainly BER but also NER
- mainly direct reversal and also BER
- mainly NER but also BER
11. DNA topoisomerase drug
- Doxorubicin
- cisplatin
- cyclophosphamide
12. What does Ku activate
13. DNA cross linking agent drug
- cyclophosphamide
- cisplatin
- doxorubicin
14. What chromatin modifcation is mediated by PARP1/2
- ADP-ribosylation of H1 and H2B
- Phosphorlyation of HP1
- S139 on H2AX for 1-2 MB around DSB
15. What is phosphorylated by DNA-PKcs
- KU
- itself and activation of recruiting proteins
- ATR
- ATM
16. Oxidative DNA damage causes
- torsional stress
- base and sugar-phosphate damage and strand breaks
- base tautormisation
- base deamination
17. MHEJ stands for
- Micro-homology- mediated End joining
- NHEJ
- HR
18. NER diseases
- XP and CT
- XP and CS
- XP and CS
- XT and CS
19. what causes helix distortions and impairs DNA transcription and replication
- base tautomerisation
- UV damage - DNA base adducts
- base deamination
20. What kinases do ATM/ATR activate