Cystic Fibrosis

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1. Which of the following statements is false?

  • Cystic fibrosis is an autosomal recessive inherited disease
  • Ivacaftor is effective in class 1 mutations
  • Raised immunoreactive trypsinogen is a diagnostic test
  • The development of diabetes is associated with CF
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2. The most common mutation class is

  • Class 3
  • Class 4
  • Class 2
  • Class 1

3. Which of these statements is false?

  • The ENaC channel moves sodium into the cells of the airways
  • In those without CF chloride ions are moved out of the cell and into sweat
  • In those without CF the ENaC channel is inhibited
  • In those with CF sodium ions are drawn into sweat

4. Which of these is not commonly involved in chronic infections of cystic fibrosis patients?

  • Haemophillius influenzae
  • Coronavirus
  • Staph aureus
  • Pseudomonas aurigenosa

5. Class 2 mutations lead to the deletion of what amino acid?

  • Lysine
  • Phenylanine
  • Glutamine
  • Arganine


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