Cystic Fibrosis 0.0 / 5 ? BiologyHealth, illness and diseaseA2/A-levelEdexcel Created by: francesca_321Created on: 11-04-16 13:23 What was a mutation of the CFTR lead to? A mutation changes the sequence of bases 1 of 11 What would this sequence of bases lead to? stop code, insertion and deletion 2 of 11 Therefore, what would not occur? transcription and translation 3 of 11 Where are the CFTR proteins? in the cell surface membrane of mucus producing cells 4 of 11 What would the change in primary structure lead to? Change in the sequence of amino acids, bonding will be different 5 of 11 What kind of protein is a CFTR molecule? Channel protein 6 of 11 What wouldnt be able to occur? no chloride ions will be able to enter of leave the CFTR protein 7 of 11 What happens when the CFTR molecule is absent or not working? less chloride ions in mucus, 8 of 11 Therefore, what happens to the mucus? stickier 9 of 11 in what body parts? respiratory system, lungs, digestive system, pancreas 10 of 11 How is the CFTR broken down? enzymes, hydrolysis of peptide bonds 11 of 11
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