lose most smoked then intranasal/oral compared to intravenous- oral route is more sustained than IV hit , intranasal delayed hit
1 of 15
Jacobs et al., (1989)
CT scan of a thalamic hemorrhage in a crack cocaine user
2 of 15
Rocha et al., (1998)
05mg/kg per injection, FR-2 schedule, with particular dosage of cocaine make responses to these doses to increase self-administration, mutant mice lacking DAT fail to show hyperactivity following psychostimulant treatment, less responding in DAT ...
3 of 15
cont
...knockout but responding doesnt stop, maybe dopamine not whole story- maybe serotonin plays a role
4 of 15
Vorel et al., (2002)
MFB stimulated electrodes, cocaine 2mg.kg iv, SB 277011-A selective D3 antagonist compltely blocked effect of cocaine- if have block in receptors, D3 used in sx/haloperidol...
5 of 15
cont
...if block receptors for a long period of time they can change- upregulate/become more sensitive
6 of 15
Pilla et al., (1999)*
reduction in cocaine seeking behaviour in rats treated with BP-8977 a partial agonist at D3 receptors
7 of 15
Inada et al., (1992)
control study in rats, locomotor activity as a proxy for cocaine use-11 days continuous iv infusion e.g. drip, 20mg/kg cocaine challenge, schedule produced tolerance, can hanfle larger doses of drug than if they have become used to it, continuous ..
8 of 15
cont
...slow release/infusion causes tolerance
9 of 15
Post and Contel (1983)
1 injection per day 10mg/kg iv per day, more spikes, increasing sterotypy shows sensitisation to dose- due to ongoing neurochemical changes in brain, saline probe injectiosn show no carry over effect, sterotypy dropped when saline injections only at
10 of 15
Griffiths et al., (1972) amphet
7 users no prior history of psychosis, 10mg dextroamphetamine every hour for up to 5 days, all psychotic within 2-5 days, auditory delusions etc
11 of 15
McCann et al., (1998)
abstinent drug users, DAT shown with radiolabeled cocaine, in assoc with LT use to get PD symp, reduced in drug users and PD
12 of 15
Hatzidimititriou et al., (1999)
squirrel monkeys and MDMA, fibres stained to show white 5mg/kg twice daily for 2 days killed 2 weeks later or 7 years later- mdma loss sertonergic fibres still show signs 7 years later
13 of 15
Norman and Cassaday (2003)
amphet increase CS salience in variety of procedures- latent inhbition, overshadowing, trace conditioning, contextual conditioning
14 of 15
Kuczenski and Segal (2002)
adolescent rats in active phase of cycle given methylphenidate/ritalin reduction in activity, oral doses every 3 hours 9 hour test period - therapeutic in ADHD
15 of 15
Other cards in this set
Card 2
Front
Jacobs et al., (1989)
Back
CT scan of a thalamic hemorrhage in a crack cocaine user
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