In what scenarios might it be useful to perform a karyotype?
Cases of recurrent miscarriage, infertility, after an array CGH or if a trisomy is suspected
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What are the disadvantages of performing a karyotype?
Must grow cells and requires expert interpretation
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What is an array CGH?
A glass slide with thousands of short sequences of DNA. Reference DNA is labelled green and test DNA is labelled red. The DNA is mixed and allowed to hybridise to the probes in order to detect deletions or duplications in the test DNA.
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What is a positive and negative of using an array CGH?
Can detect contiguous gene syndrome, cannot detect single gene disorders
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What is QF-PCR
Counts chromosomes in order to detect trisomies
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Other cards in this set
Card 2
Front
What are the disadvantages of performing a karyotype?
Back
Must grow cells and requires expert interpretation
Card 3
Front
What is an array CGH?
Back
Card 4
Front
What is a positive and negative of using an array CGH?
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