Chemical messengers

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  • Created by: ksjvsba
  • Created on: 17-01-16 15:48
NMDA receptors require what in order to become activated?
glycine as well as glutamate, receptor function can be modifyed rather than a simple open or close mechanism
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Criteria for NT
should posses machinery for synthesis and storage of substance, sub should be released from neurons by exocysosis, substance should interact with specific membrane receptors, mechanisms for inactivation should exist.
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How fast are fast ionotrophic receptors
ms-secs
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GPCR are
sec-mins
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Synaptic Plasticity
mins-hours
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NM produce
slower pre-/post synaptic responses than NTs and produce ST/LT changes (neuronal gene modification). 100s-mins
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Nitric Oxide
produced following a ride in intracellular calcuim . Once produce it is release immediated (not NT).
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ST Nitric oxide
activates enzyme (guanlate cyclase) -> 2nd messenger (cGMP) -> phosophalte cascades-> inhib and excit effects
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LT Nitric oxide
reacts with free readicals to produce peroxynitrile -> highly toxic -> neuronal death
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Endocannibinoids
Retrograde messegers -> CB1 is a GPCR mediates THC. Examples anadimine and 2-Ag.
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Criteria for NT

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should posses machinery for synthesis and storage of substance, sub should be released from neurons by exocysosis, substance should interact with specific membrane receptors, mechanisms for inactivation should exist.

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How fast are fast ionotrophic receptors

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GPCR are

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Synaptic Plasticity

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