Proteins targeted to organelles have uptake target sequences Often cleaved upon entry to organelle
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Where are matric targeting sequences found?
at the amino terminus. Genes for proteins found in mitochondrial matrix have coding nucleotides for matrix targeting sequences, which is cleaved in the mature protein.
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What do chaperones do?
prevent the protein from folding or can help the protein to fold.
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What is Path A used by?
proteins that have a matrix targeting sequence and an internal stop transfer sequence.
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What is Path B used by?
proteins that enter the matrix and then the MTS is cleaved.
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What is Path C used by?
multipass proteins. There is no MTS, but several internal targeting sequences (ITS).
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Card 2
Front
Where are matric targeting sequences found?
Back
at the amino terminus. Genes for proteins found in mitochondrial matrix have coding nucleotides for matrix targeting sequences, which is cleaved in the mature protein.
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