Cells as systems

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Systems
Creating systems on computers to explain simple biological theories, based on human organelles
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Reductionist
Whole organism is broken down to the DNA
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Integrative
Biology is built up from DNA to whole organism
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3 stages of cellular systems
Energy (metabolism and transport), Information (transcription, translation), Cell fate processes (cell growth, adhesion, differentiation).
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Signalling modification
Proteins, influenced for transcription factors that instruct growth of different cell types.
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Biology cycles
Predictions & hypothesis generation -> component characterisation/model refinement -> network reconstruction
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Eukaryotes protein map
Eukaryotes have a more complex genome. 20% of proteins have an unknown function
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Network maps
Cells have cell processes to perform many different functions, they have sub systems, with overlaps/
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Moonlighting proteins
Proteins that can perform many different tasks. They are highly interactive.
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Computational systems biology
Used to develop efficient algorithms, data structures and communication tools. Used to understand the information and find relationships between proteins.
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BioNumbers
BNID used for protein identification.
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Envelope calculations
Estimate= square root of X lower times X upper
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Other cards in this set

Card 2

Front

Whole organism is broken down to the DNA

Back

Reductionist

Card 3

Front

Biology is built up from DNA to whole organism

Back

Preview of the back of card 3

Card 4

Front

Energy (metabolism and transport), Information (transcription, translation), Cell fate processes (cell growth, adhesion, differentiation).

Back

Preview of the back of card 4

Card 5

Front

Proteins, influenced for transcription factors that instruct growth of different cell types.

Back

Preview of the back of card 5
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