Cell biology 9S.2 0.0 / 5 ? BiologyIntracellular signal transductionUniversityAll boards Created by: Jasmine FinchCreated on: 24-05-20 18:56 Effect of adrenaline epinephrine, G protein coupled receptor, adenylyl cyclase, CAMP,protein kinase A 1 of 13 What happens when nerve cells are incubated with seratonin? level of CAMP rises 2 of 13 In the endothelial cells acetylcoline induces activation of GPCR through phospholipids 3 of 13 How can signals be turned off? receptor sequesturation, receptor-down regulation, receptor inactivation,inactivation of signalling protein and induction of inhibitory protein 4 of 13 How does GPCR kinase desensitize the GPCR? GPCR activated, Stimulates GPK to phosphorylate GPCR on multiple sites, ATP-ADP, Arrestin binds to phophorylated GPCR and GPCR is desensitized 5 of 13 PKA targets and activates the phophodiesterase which lowers cAMP levels. This negative feedback converts what might be a prolong effect to a short one 6 of 13 Types of enzyme coupled receptors receptor tyrosine kinase, tyrosine kinase associated receptor and receptor serine-threonine 7 of 13 RTKS trigger activation of Ras protein and activated Ras triggers a downstream kinase cascade 8 of 13 Activated Ras binds and activates Raf 9 of 13 Raf phophylates Mek 10 of 13 Mek phosphrylates Erk 11 of 13 Erk enters the nucleus and activates the expression of G1 cyclins 12 of 13 Effects of amplification increased sensitivity, risk of unwanted triggering and no way to turn off signal without additional mechanism 13 of 13
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