Cell Biology 8S.1 0.0 / 5 ? BiologyCell maintenance, death, stress and repairUniversityAll boards Created by: Jasmine FinchCreated on: 24-05-20 15:17 What are the two types of DNA damage SSB (single strand break) and DSB (double stand break) 1 of 16 Depurination 'loss of memory'-5000 per cells per day 2 of 16 Deamination loss of amine group 3 of 16 How can mutations be fixed during DNA replication base pair deleted or opposite base pairs, bases changed to another or remains unchanged 4 of 16 Is DSB or SSB harder to repair? BSB and more important to repair as; no template, disrupts DNA replication and thus proteins effected 5 of 16 Two strategies for repair non-homolgous end joining and homologous recombination 6 of 16 DNA damage activates p53 which exerts its tumour supressor effects. 7 of 16 what are the 4 main reponses of p53? cell cycle arrest, DNA repair, Apoptosis and Inhibition of anglogenesis 8 of 16 p53 can activate DNA repair via activation of p21 and XPC 9 of 16 Protein folding begins when during translation at the ribosome 10 of 16 Heat shock protein- 70 binds hydrophobic regions of unfolded proteins to prevent aggregation. It binds to unfolded proteins before they leave the ribosome 11 of 16 HSP60 provides a protected environment for protein folding. It binds to unfolded proteins after they leave the nucleus 12 of 16 Glycosylation is important for appropriate folding of proteins synthesised in the ER 13 of 16 Calnexin and calretialin are chaperones that prevent imcomplexity folded proteins from aggregating 14 of 16 heat shock is a form of negative feedback allowing cells to adapt to stress 15 of 16 What are the two forms of cell death? necrosis and apoptosis 16 of 16
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