Cell Biology 8S.1

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What are the two types of DNA damage
SSB (single strand break) and DSB (double stand break)
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Depurination
'loss of memory'-5000 per cells per day
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Deamination
loss of amine group
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How can mutations be fixed during DNA replication
base pair deleted or opposite base pairs, bases changed to another or remains unchanged
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Is DSB or SSB harder to repair?
BSB and more important to repair as; no template, disrupts DNA replication and thus proteins effected
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Two strategies for repair
non-homolgous end joining and homologous recombination
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DNA damage activates
p53 which exerts its tumour supressor effects.
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what are the 4 main reponses of p53?
cell cycle arrest, DNA repair, Apoptosis and Inhibition of anglogenesis
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p53 can activate DNA repair via activation of
p21 and XPC
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Protein folding begins when
during translation at the ribosome
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Heat shock protein- 70
binds hydrophobic regions of unfolded proteins to prevent aggregation. It binds to unfolded proteins before they leave the ribosome
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HSP60
provides a protected environment for protein folding. It binds to unfolded proteins after they leave the nucleus
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Glycosylation is important for
appropriate folding of proteins synthesised in the ER
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Calnexin and calretialin are
chaperones that prevent imcomplexity folded proteins from aggregating
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heat shock is a form of
negative feedback allowing cells to adapt to stress
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What are the two forms of cell death?
necrosis and apoptosis
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Other cards in this set

Card 2

Front

Depurination

Back

'loss of memory'-5000 per cells per day

Card 3

Front

Deamination

Back

Preview of the front of card 3

Card 4

Front

How can mutations be fixed during DNA replication

Back

Preview of the front of card 4

Card 5

Front

Is DSB or SSB harder to repair?

Back

Preview of the front of card 5
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