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Card 6

Front

What was observed when KCNE1 was over expressed in oocytes?

Back

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Card 7

Front

Does the expression of KCNQ1 alone or KCNQ1 + KCNE1 (Iks current) produce faster current activation?

Back

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Card 8

Front

What does the relative shift to the right seen in a graph recording current produced by KCNE1 and KCNQ1 together compared to KCNQ1 alone mean about potential cells with both proteins need to reach a certain current?

Back

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Card 9

Front

While LQT syndrome is fairly asymptomatic until the patients teenage years or during exercise - possibly related to hormone levels, what are some symptoms that do characterize the disease

Back

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Card 10

Front

There are both autosomal dominant and recessive forms of LQT syndrome, how many different forms of LQT syndrome are known of all together?

Back

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Card 11

Front

An example of a QT interval which is too long is 0.54s as this is longer than usual every now and then there will be a mismatch in the cardiac cycle. What is the normal length of a QT interval at rest?

Back

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Card 12

Front

What effect on Iks currents (from KCNQ1 channels) do these mutations in KCNE1 proteins have; V47F, L51H, D76N, W87R?

Back

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Card 13

Front

What are the 3 potential mechanisms of action impacted by mutations in KCNE1 proteins?

Back

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Card 14

Front

Which KCNE1 mutation results in smaller Iks currents similar to when KCNQ1 is expressed alone and thus demonstrates/provides supporting evidence for the role of KCNE1 in gating KCNQ1?

Back

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Card 15

Front

What was observed about KCNE1 localisation when the L51H KCNE1 mutant was expressed in permeablised and non permeabilized cells compared to WT KCNE1 proteins using antibodies and FLAG?

Back

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