More cards in this set
Card 6
Front
What was observed when KCNE1 was over expressed in oocytes?
Back
Card 7
Front
Does the expression of KCNQ1 alone or KCNQ1 + KCNE1 (Iks current) produce faster current activation?
Back
Card 8
Front
What does the relative shift to the right seen in a graph recording current produced by KCNE1 and KCNQ1 together compared to KCNQ1 alone mean about potential cells with both proteins need to reach a certain current?
Back
Card 9
Front
While LQT syndrome is fairly asymptomatic until the patients teenage years or during exercise - possibly related to hormone levels, what are some symptoms that do characterize the disease
Back
Card 10
Front
There are both autosomal dominant and recessive forms of LQT syndrome, how many different forms of LQT syndrome are known of all together?
Back
Card 11
Front
An example of a QT interval which is too long is 0.54s as this is longer than usual every now and then there will be a mismatch in the cardiac cycle. What is the normal length of a QT interval at rest?
Back
Card 12
Front
What effect on Iks currents (from KCNQ1 channels) do these mutations in KCNE1 proteins have; V47F, L51H, D76N, W87R?
Back
Card 13
Front
What are the 3 potential mechanisms of action impacted by mutations in KCNE1 proteins?
Back
Card 14
Front
Which KCNE1 mutation results in smaller Iks currents similar to when KCNQ1 is expressed alone and thus demonstrates/provides supporting evidence for the role of KCNE1 in gating KCNQ1?
Back
Card 15
Front
What was observed about KCNE1 localisation when the L51H KCNE1 mutant was expressed in permeablised and non permeabilized cells compared to WT KCNE1 proteins using antibodies and FLAG?