BMS1031 human genetics 0.0 / 5 ? Biologymolecular biology, genetics UniversityAll boards Created by: tammyrocks4evaCreated on: 27-05-14 15:37 In which direction does DNA polymerase move? 5' to 3' 1 of 40 What is the start codon for translation in mRNA? AUG 2 of 40 Which AA causes a 'kink' in the polypeptide chain? Proline 3 of 40 What structure is found on the 5' end of a mature mRNA? CAP 4 of 40 What is the process in eukaryotes whereby ribosomes find the start site of translation? Scanning 5 of 40 What is the name of the process by which sugar molecules are added to a polypeptide? Glycosylation 6 of 40 All of these can be found in chromatin EXCEPT? Ribosomes 7 of 40 Centromeres.....? A and C 8 of 40 Heterochromatin....? B and C 9 of 40 Nucleosomes...? Are naked DNA 10 of 40 All of these are true EXCEPT...? Nucleosomes are the string in the beads on a string chromatin fibre 11 of 40 The histone octamer core comprises...? 2xH2A/H2B + 2xH3/H4 12 of 40 What diameter is the chromatin fibre in a chromatid? 700nm 13 of 40 What is the size of the human genome? 3x10^9 bp 14 of 40 How many protein coding genes are there in the human genome? 3x10^4 15 of 40 What differentiates retrotransposons from any other mobile genetic elements? RNA intermediate 16 of 40 A TATA box...? Positions RNA polymerase 17 of 40 An enhancer is...? Position and orientation independent 18 of 40 Which enzyme transcribes mRNA? RNA polymerase II 19 of 40 A reporter gene assay...? Tests for transcriptional activity 20 of 40 An electrophoretic mobility shift assay (EMSA)...? Directly shows binding of nuclear proteins to a specific part of the promoter 21 of 40 Transcriptional activators always have a...? C) Transcriptional activation domain 22 of 40 A homodimeric nuclear receptor...? Translocates into the nucleus on ligand binding 23 of 40 A heterodimeric nuclear receptors...? Is exclusively in the nucleus 24 of 40 What does heterodimeric nuclear receptors do at/to its target genes in the absence of ligand? Promotes histone deacetylation 25 of 40 A homodimeric nuclear receptor binds to...? Inverted repeats 26 of 40 How is diversity generates during meiosis? Synapsis and crossing over 27 of 40 How many (minimum) mutant (disease) genes does someone affected with an autosomal recessive disease have? two 28 of 40 An example of an autosomal recessive disease is? phenylketonuria 29 of 40 An example of an X linked recessive disease is...? duchenne muscular dystrophy 30 of 40 The phenotype of an individual heterozygous for a codominant mutation is...? Intermediate between the wildtype and mutant homozygotes 31 of 40 One X chromosome in females is randomly inactivated by...? Xist 32 of 40 Single nucleotide polymorphisms are...? common 33 of 40 A base change in the promoter region may prevent...? Transcription 34 of 40 A base change in the coding sequence may...? All the things 35 of 40 A base change that leads to insertion of a stop codon may cause mRNA to be degraded by...? Nonsense-mediated decay 36 of 40 What is the name of the tandem repeat of type CA(n) or CACACACACA? Microsatellites 37 of 40 Anticipation in triplet repeat diseases means...? Phenotype worsens as repeat number increases 38 of 40 How many genes would you expect to be involved in a complex disease? Many 39 of 40 How would you investigate the genetics of a complex disease in an unrelated population? Association studies 40 of 40
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