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6. Approximately how much of HbA is HbF?
7. What is the maximum volume of O2 that will bind to 1g of haemoglobin?
- 1.66 ml
- 1.46 ml
- 1.36 ml
- 1.56 ml
8. At a PaO2 of 13.3 kPa, approximately how saturated is venous blood?
9. Why do sickle cell abnormalities not manifest themselves until approximately 6 months of age?
- At 6 months, HbA starts to replace HbF
- At 6 months, the child learns to stand upright and walk
- At 6 months, Glycine is switched for Leucine at Codon 3
- At 6 months, there is a large increase in the quantity of erythropoeitin
10. True or false: sickling leads to shortened erythrocyte survival and impaired flow through the microcirculation?
11. What is the specific mutation for sickle cell disease?
- Valine for Glutamine at Codon 6
- Glycine for Leucine at Codon 3
- Adenine for Cytosine at Codon 4
- Cytosine for Guanine at Codon 5
12. Which of the following is Henry's Law?
- gas = partial pressure / solubility coefficient
- [gas in solution] = partial pressure x solubility coefficient
- [gas in solution] = partial pressure / solubility coefficient
- gas = partial pressure x solubility coefficient
13. Approximately what is the average cardiac output of a heart in l/min?
- 4 l/min
- 2 l/min
- 5 l/min
- 3 l/min
14. Which of the following can be a clinical cause of anaemia?
- FBC
- Haematopoeisis
- Haemolysis
- LMR
15. Which of the following symptoms is common as a result of thalassaemia?
- Decreased erythropoiesis
- Decreased flow through mitochondrion
- Increased erythropoiesis
- Increased flow through mitochondrion
16. In terms of pressure, what is 1 mmHg equal to?
- 13.3 kPa
- 750 kPa
- 0.133 kPa
- 7.5 kPa
17. True or false: the partial pressure of any individual gas is independent of other gases in a mixture?
- The Prime Minister
- True
- No
- False
18. What is the approximate oxygen content of normal arterial blood?
- 100 ml/l
- 200 ml/l
- 150 ml/l
- 250 ml/l
19. Which of the following symptoms is common as a result of thalassaemia?
- Increased haemolysis of mature cells
- Decreased sticking of haem groups
- Decreased haemolysis of mature cells
- Increased sticking of haem groups
20. What is the normal haemoglobin range in women?
- 15.5-20.0 g/100ml
- 16.5-18.5 g/100ml
- 11.5-16.0 g/100ml
- 10.0-12.2 g/100ml