biological explanations for schizophrenia

what is neural correlate?
they are measurements of the structure or function of the brain that correlates with an experience.
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what is the ventral stratum involved with?
it is believed to be involved in motivation and anticipation of an reward, links to avolution. there is a negative correlation between activity levels and severity of the symptoms.
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what was Allens research?
He scanned the brains of patients experiencing auditory hallucinations and compared to a control group, whilst they identified prerecorded speech as themselves or others.
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what were the results of Allens research?
lower activation levels in superior temporal gyrus and anterior cingulate gyrus, therefore made more errors.
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what is the amphetamine hypothesis?
when you have prolonged severe substance abuse of things like cocaine, it can alter the structure of your brain, brain has been overstimulated so produced more DA 2 receptors, this may be the same for people with schizophrenia.
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what is the dopamine hypotheses?
the idea that the levels of dopamine in certain areas of the brain will cause them to experience symptoms of schizophrenia.
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describe hyperdopaminergia in the subcortex.
high levels of the dopamine in areas in the centre of the brain, such as overactivity in brooks area can be associated with speech poverty and auditory hallucinations.
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describe hypodopaminerga in the cortex.
abnormal dopamine levels in the brains cortex, identified that low levels of dopamine in the prefrontal cortex played a role in the negative symptoms such as evolution and speech poverty.
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what does it mean when schizophrenia is described as being polygenic.
more than one gene is involved in the inheritance
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describe Ripkes research.
he combined all previous date from genome wide studies of schizophrenia, 37,000 patients compared to 113,000 controls.
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what were the results of Ripkes research?
108 sperate genetic variations were associated with the risk of schizophrenia.
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what is the ventral stratum involved with?

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it is believed to be involved in motivation and anticipation of an reward, links to avolution. there is a negative correlation between activity levels and severity of the symptoms.

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what was Allens research?

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what were the results of Allens research?

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what is the amphetamine hypothesis?

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