Biological Explanations for Obesity

Chaput (2014)

Concordance rate of 1st degree relatives = 20-50%

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Nan (2012)

Meta-analysis of 12 major twin studies found 61-80% concordance

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Locke (2015)

Genomes of 300k people, 97 genes associated with 3% of BMI variations so polygenic

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Stunkard (1986)

Found strong relationship with bio parents but none with adoptive parents

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Paracchini (2005)

Meta-analysis found no evidence of the link between leptin regulating genes and obesity

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Wang et al (2001)

Significantly fewer dopamine D2 receptors in striatum, which effectively stopped reward system

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Ohia (2013)

Mice genetically engineered to have no serotonin 2C receptors develop late-onset obesity

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Ritchie and Noble (2003)

PET scans found people who inherited one version of the DRD2 gene has 30-40% fewer D2 receptors

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Meta-analysis of 12 major twin studies found 61-80% concordance

Nan (2012)

Genomes of 300k people, 97 genes associated with 3% of BMI variations so polygenic

Found strong relationship with bio parents but none with adoptive parents

Meta-analysis found no evidence of the link between leptin regulating genes and obesity

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