Where the zygote becomes a multicellular organism composed of trillions of cells, has specialised functions.
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Devvelopment is a combination of 2 things:
Differentiation and morphogenesis.
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What is morphogenesis?
The processes which shape the cell
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Development is cell biology in action, what type of stuff will be covered?
Cell proliferation (cell cycle), cell death (apoptsis) changes in cell shape/cell movement (cytoskeleton), positional (information cell signalling.)
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What are good model organisms?
Nematode, fruit fly, zebra fish, african clawd toad, chicken, mouse
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What are the early processes that happen during early development? Amphibian
Fertilization, cleavage (the cells get smaller and smaller in size),
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What is ZPA?
Zone of polarising Activity
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What does ZPA do
Secretes a morphagen that diffuses across the limb bud,
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Where are ZPA morphagen concs highest.
Highest on the posterior side, and lowest on the anterior
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How does the kidney develop?
The tubular epithelium arises from a little bud in the embryonic kidney. There is a mesenchyme cell. As the bud begins to branch, the mesenchyme bud starts to trnasition to tubular epithelial cells. Organised into a tubular cell, fusing with the bud
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What induces the branching process?
The bud
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What is the Ret RTK required for?
Kidney development
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If you knock out the Ret gene, what do you get?
You get ureters but they are blind ended.
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What does the Ret gene express?
Receptor tyrosine kinase
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Where is the receptor tyrosine kinase expressed?
On the top of the ureteric bud
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Ret is the ...
Receptor for the signal of kideny formation
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When does the bud not branch?
In GDNF, GDNFR or Ret knockout
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Where does the GDNF made from?
The mesenchyme
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GDNFR is a co receptor for..
GDNR
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How is the GNFR a attached?
By a GPI anchor
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What is the ureteric bud signal?
Leukaemia inhibitory factor (LIF)
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Other cards in this set
Card 2
Front
Devvelopment is a combination of 2 things:
Back
Differentiation and morphogenesis.
Card 3
Front
What is morphogenesis?
Back
Card 4
Front
Development is cell biology in action, what type of stuff will be covered?
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