BI503- Cell Biology

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1. Which of the following descriptions best matches the PERK arm of the ER unfolded protein response (UPR)

  • It involves regulated proteolysis of the sensor protein in the Golgi apparatus.
  • It inhibits a protein translation initiation factor by phosphorylation
  • Its sensor bears both kinase and endoribonuclease activities
  • It involves a noncanonical cytoplasmic splicing process.
  • Its sensor is a latent transcription regulator.
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2. The flexibility of a biological membrane is strongly influenced by;

  • the lipid headgroups of the lipid constitutents
  • all the above
  • Temperature
  • pH
  • ionic strength

3. The following diagram depicts the topology of a multipass transmembrane protein in the endoplasmic reticulum (ER) membrane. Which set of helices act as stop-transfer signals in this protein?

A 6 transmembrane protein N -1 -2 -3 -4 -5 -6 -C. N and C in th

  • 4,5,6
  • 1,2,3
  • 2,4,6
  • 1,6
  • 1,3,5

4. What is the typical thickness of a lipid bilayer such as the plasma membrane of our cells?

Select one:

  • 100nm
  • 500nm
  • 5nm
  • 50nm
  • 0.5nm

5. The two monolayers of the plasma membrane in a human red blood cell …

  • have different overall electrical charges, with negatively charged phospholipids (e.g. phosphatidylserine) normally enriched in the inner monolayer.
  • both contain glycolipids
  • exchange phospholipids only through spontaneous flip-flops.
  • have the same abundance of phosphatidylinositol.
  • both contain gangliosides.
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