The basic cognitive defect… is an awareness of automatic processes which are normally carried out below the level of consciousness
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Maher, 1983
Schizophrenics show a “failure of attentional focusing to respond to stimulus redundancy”
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Hemsley, 1987
Schizophrenics are less able to make use of the redundancy and patterning of sensory input
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Cutting, 1985)
Schizophrenics “concentrate on detail at the expense of theme
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Griffith et al., (1972)
7pp no prior psycho given 10mg dextroamph every hour for 5 days all psychotic within 2-5days delusions
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Goldman-Rakic, 2004
D1 agonists to boost DA hypo-function in frontal cortex?
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Lubow’s
first method for testing LI in human pp- US = counter increment Task to work out which of a series of nonsense syllables (e.g., pev, jic) predicts the counter increment CS in fact a white noise-
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Baruch et al., 1988)
Link between the loss of LI and SZ shown using the counter increment variant
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Gray et al., 1996
Amphetamine treatment abolishes LI in ‘normal’ human participants (single 5 mg dose
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Williams et al., 1997, 1998)
Haloperidol can reduce LI in humans - can actually make it worse
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Kumari et al., 1999
Haloperidol effects in healthy humans depend on Psychoticism scores – human variation in the normal range- characteristics in that direction (single 5 mg dose
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...
Pre exposed learn better Haloperidol only beneficial in high psychoticism groups (right side of graph)
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Shrira and Kaplan, (2009)
Li reduced with sx- with vs without masking reduced effect in high sx group not seen under all conditioned- low Sx and high Sx with masking sig dif
Loss of the “selectivity which normal attention ordinarily exercises among the sensory impressions
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Weiner et al., (1997)
Give amphet, more sensitive to shock, Latent inhib normal with haloperidol and amphet Enahnced inhib with halo on its own
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Cassaday and Moran, (2010)
Li is reliably reduced by excitotoxic lesions to shell region of NAc, also influence of frontal
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Maher, 1983)
Schizophrenics show a “failure of attentional focusing to respond to stimulus redundancy
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Hemsley, 1987
Schizophrenics are less able to make use of the redundancy and patterning of sensory input” (
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Nelson et al., (2011)
Da in DAx - salience modulation in LI and overshadowing ...
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part 2...
Localised injections When infused amphet in these tubes LI- after stim pre exp amphet in core sub region, but shell affected Brain regions all work in shell Dissoc LI and overshadowing 2 ways of mani salience of cue for learning not equip for
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Other cards in this set
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Front
Maher, 1983
Back
Schizophrenics show a “failure of attentional focusing to respond to stimulus redundancy”
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