Anti-Psychotic Medication

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What does APM aim to do?
Reduce, modulate or stabilise the balance of dopamine in 4 key pathways
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What are the two different types of APM?
Typical and Atypical
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What did older AP's do?
Targeted dopamine receptor sites
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What do newer AP's do?
Try to stablise Neurotransmitters
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How often do patients need to take APM?
On a regular basis
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How long does it take for APM to work?
Around 10 days
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Name a typical AP?
Chlorpromazine
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What do typical AP's aim to do?
Antagonise levels of dopamine in the brain
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How do typical anti-psychotics work?
They bind to receptor sites which lowers transmission
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What can be caused by the action of typical anti-psychotics?
Permanent blockage of receptor sites which cause negative motor symptoms
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Name an Atypical AP?
Seroquel
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What do Atypical AP's aim to do?
Modulate dopamine and serotonin levels in key pathways
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How do Atypical Ap's work?
Either increase or decrease levels of Neurotransmitters
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What do atypical AP's do in the mesolimbic dopamine pathway?
Decrease dopamine levels
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Why target the mesolimbic dopamine pathway?
Reducing dopamine levels in this pathway reduces positive symptoms
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What action in the mesolimbic pathway stops negative motor symptoms?
The rapid dissociation or hit and run action
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What does the hit and run action allow for?
Allows the receptors to become available for natural processes, which helps avoid negative side effects
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What do atypical AP's do in the nigrostriatal dopamine pathway?
Increase dopamine levels
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Why target the nigrostriatal dopamine pathway?
Blockage of dopamine receptor sites here causes negative motor side effects such as tardive dyskinesia
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What action in the nigrostriatal pathway stops negative motor symptoms?
The prevention of serotonin admission which allows for natural dopamine levels
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Card 2

Front

What are the two different types of APM?

Back

Typical and Atypical

Card 3

Front

What did older AP's do?

Back

Preview of the front of card 3

Card 4

Front

What do newer AP's do?

Back

Preview of the front of card 4

Card 5

Front

How often do patients need to take APM?

Back

Preview of the front of card 5
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