ANDROGENS

androgens

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  • Created by: Rosa
  • Created on: 12-05-13 23:18
ANABOLIC STEROIDS (nandorol)
androgens modified to have anabolic effects. inc protein syth (enhance muscle develop) used to treat itching of CHRONIC BILIARY OBSTRUCTION in some aplastic aneamias. terminal cond (inc appetite and ewell being). metastatic mammary cancer.
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anabolic steroids cont
S.E. cholestatic jaundice, testiculatr atrophy, sterility. women: deep voice, inbi ovulation, acne, alopecia. inc risk of coronary heart disease.
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ANTI-ANDROGENS
estrogens and progest have anti-andro activity as i9nhibit gonadotrophiu secretion. progesterone compete in target organs.
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anti-androgen: FLUTAMIDE
used to treat advanced prostate cancer, inhibits tumour flare gonadrelin analogue admin. SE: nausea, fatigue, GI tract disturbances, decre libido and sperm count, insomnia
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anti-androgen: FINASTERIDE
inhibits 5[alpha] reductase so blocks DHT. SE: impotence, testicular pain, decre libido. breast enlaregment and pain (women)
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GONADOTROPHIN ANALOGUES
pituatry secretes lH and FSH (gonadotrophins) found in post-meno due to lack of inhibition on pituitary by estrogen. injected. treat infertility caused by lack of ovulation also to induce ovulation for invitro fertilizationand re-implantation.
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GONADOTROPHIN-RELEASING HORMONE (agonists/antagonsists)
initially stimulate release but then depress it by desensitization of receptors in pituitary. used to treat metastatic prostate cancer by causing androgen depletion
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GnRH: GOSERELIN
causes tumour flare initially due toi iuncreased secretion of androgens but used with FLUTAMIDE to prevent this. SE: infertility, impotence, loss of libido, sleep disturbances, transient changes in B.P
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Other cards in this set

Card 2

Front

S.E. cholestatic jaundice, testiculatr atrophy, sterility. women: deep voice, inbi ovulation, acne, alopecia. inc risk of coronary heart disease.

Back

anabolic steroids cont

Card 3

Front

estrogens and progest have anti-andro activity as i9nhibit gonadotrophiu secretion. progesterone compete in target organs.

Back

Preview of the back of card 3

Card 4

Front

used to treat advanced prostate cancer, inhibits tumour flare gonadrelin analogue admin. SE: nausea, fatigue, GI tract disturbances, decre libido and sperm count, insomnia

Back

Preview of the back of card 4

Card 5

Front

inhibits 5[alpha] reductase so blocks DHT. SE: impotence, testicular pain, decre libido. breast enlaregment and pain (women)

Back

Preview of the back of card 5
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