Adpative Immunity 0.0 / 5 ? BiologyPathobiologyUniversityNone Created by: SarahCreated on: 03-05-17 20:25 what are the main features of adaptive immunity? SMT= specific, memory, tolerance 1 of 28 examples of APCs? fixed and free macrophages eg kupffer cells, monocytes and microglia. B lymphoctes 2 of 28 where are APCs? epithelia and endothelia 3 of 28 what do APCs do? display fragments of invaging pahogens on their surface and present to IS cells 4 of 28 what is an MHC? marjor histocompatibility complex- cell surface glycoproteins that bind antigens and present them 5 of 28 what MHCs are more common? why? MHC I- they're in all nucleated cells, constitutive 6 of 28 what do MHC I activate? Cytotoxic T cells 7 of 28 what do CD4 + T helper cells do? activate cytotoxic cells, form memory T cells 8 of 28 where are MHC II's found? in APCs 9 of 28 what do MHC IIs activate? T helper cell 10 of 28 what evokes T helper cell activation and division? a receptor binding 11 of 28 what do cytotix T cells do? perforin,lymphotoxin, apoptosis 12 of 28 what form of Immunoglobin is the most common in blood? IgG 13 of 28 What Ig is most common in the body overall? IgA, abundant secretion by mucous membranes 14 of 28 5 types of Igs? MADGE 15 of 28 each mature B cell produces what? 1 variant of Igs and recognises only 1 epitope (bit on antigen recognised) 16 of 28 what is the structure of Igs? antigen binding site and heavy chain tail regions 17 of 28 why does each mature b cell recognise only one epitope? hypervariable regions of antigen binding sites 5-10 aa's 18 of 28 what do follicular dendritic cells do? make the Ig a reasonable fit for the antigen gets it the right shape 19 of 28 what do Fc receptors bind? Fc rgion of antibody 20 of 28 what has Fc receptors? macrophages 21 of 28 how is the bacteria going to die by being engulfed by a macrophage? antibodys all attach to bacteria with tails tick out (fc region), the tail of antibody binds to Fc rec on macrophage 22 of 28 what is the process of losing self reacitive lymphocytes? where does it happen? clonal deletion, in the thymus 23 of 28 where are B cells in lymphoid tissue? cortex (follicular zone) 24 of 28 where re T cells in lymphoid? paracortex ( intefollicular zone) 25 of 28 what cells populate therough the lymphoid tissue T cells, B cells and APCs 26 of 28 what happens to cells on antigen presentation? lymphocyte mobilization, cells divide and migrate to infection 27 of 28 what atttracts immune cells to the location of damage? chemokines 28 of 28
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