Addiction 0.0 / 5 ? PsychologyAngelaUniversityAll boards Created by: ruby_wardenCreated on: 13-05-17 16:46 Hirvonen et al (2012) Cannabanoid receptors (PET scan) regional decrease = tolerance, can reverse 1 of 10 Siegel (1975) conditioned tolerance - only rats delivered morphine in same environment show tolerance 2 of 10 Olds & Milner (1984) rats repeatedly press lever to stimulate mesolimbic DA pathway 3 of 10 Caine & Koob (1994) rats press for cocaine, then sever pathway, appears as though not receiving drug 4 of 10 Robinson & Berridge (2000) Incentive-sensitisation model - repeat use leads to sensitisation of mesolimbic Da pathway- causing pathological motivation (wanting) 5 of 10 Bromberg-Martin et al (2008) differentiated motivational value and motivational salience - encoded by different neurons 6 of 10 Volkow (2010) used competitive binding of dopamine to show that addicts show dopamine to drug cue, not drug itself 7 of 10 Brunner & Henn (1993) Mice with serotonin knocked out = more aggressive & more likely to self administer cocaine 8 of 10 Koob (2013) role of reward and stress systems, found that reduced CRF (stress hormone) = reduced reaction to drug 9 of 10 Koob & Le Moal (2008) reward and anti-reward, withdrawal is stressful! impulsivity = positive reinforcement, compulsivity = negative reinforcement 10 of 10
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