Addiction

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Hirvonen et al (2012)
Cannabanoid receptors (PET scan) regional decrease = tolerance, can reverse
1 of 10
Siegel (1975)
conditioned tolerance - only rats delivered morphine in same environment show tolerance
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Olds & Milner (1984)
rats repeatedly press lever to stimulate mesolimbic DA pathway
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Caine & Koob (1994)
rats press for cocaine, then sever pathway, appears as though not receiving drug
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Robinson & Berridge (2000)
Incentive-sensitisation model - repeat use leads to sensitisation of mesolimbic Da pathway- causing pathological motivation (wanting)
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Bromberg-Martin et al (2008)
differentiated motivational value and motivational salience - encoded by different neurons
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Volkow (2010)
used competitive binding of dopamine to show that addicts show dopamine to drug cue, not drug itself
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Brunner & Henn (1993)
Mice with serotonin knocked out = more aggressive & more likely to self administer cocaine
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Koob (2013)
role of reward and stress systems, found that reduced CRF (stress hormone) = reduced reaction to drug
9 of 10
Koob & Le Moal (2008)
reward and anti-reward, withdrawal is stressful! impulsivity = positive reinforcement, compulsivity = negative reinforcement
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Card 2

Front

conditioned tolerance - only rats delivered morphine in same environment show tolerance

Back

Siegel (1975)

Card 3

Front

rats repeatedly press lever to stimulate mesolimbic DA pathway

Back

Preview of the back of card 3

Card 4

Front

rats press for cocaine, then sever pathway, appears as though not receiving drug

Back

Preview of the back of card 4

Card 5

Front

Incentive-sensitisation model - repeat use leads to sensitisation of mesolimbic Da pathway- causing pathological motivation (wanting)

Back

Preview of the back of card 5
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