Acyl Chloride/Acid Anhydride reactions

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What is mechanism for reaction with acyl chloride?
nucleophilic addition-elimination
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acyl chloride reaction with water (1) speed of reaction & conditions (2) products
(1) vigorous with cold water (2) produces carboxylic acid + HCl
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acyl chloride reaction with alcohols (1) speed of reaction & conditions (2) products
(1) vigorously with alcohols at room temp (2) produce ester + HCl
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acyl chloride reaction with ammonia (1) speed of reaction & conditions (2) products
(1) vigorously with ammonia at room temperature (2) produce amiDe + HCl
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acyl chloride reaction with primary amines (1) speed of reaction & conditions (2) products
(1) vigorously with primary aminesa t room temperature (2) N-Substituted amiDe + HCl
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Reactions with acid anhydrides work in same way as acyl chlorides but...
are less vigorous and instead of HCl you get a carboxylic acid
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manufacture of asprin: reagents
salicylic acid, ethanoic anhydride
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manufacture of asprin: products
asprin, ethanoic acid
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acyl chloride reaction with water (1) speed of reaction & conditions (2) products

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(1) vigorous with cold water (2) produces carboxylic acid + HCl

Card 3

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acyl chloride reaction with alcohols (1) speed of reaction & conditions (2) products

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Preview of the front of card 3

Card 4

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acyl chloride reaction with ammonia (1) speed of reaction & conditions (2) products

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Card 5

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acyl chloride reaction with primary amines (1) speed of reaction & conditions (2) products

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