34 More on hypothalamus

?
  • Created by: LUFCMazza
  • Created on: 07-08-20 23:17
GnRH
- binds gonadotrophs -- release of gonadotrophins (LH and FSH)
1 of 32
FSH
Follicle development, ovulation in ovaries, Sertoli cells (sperm production)
2 of 32
LH
Growth of corpus luteum -- secretes testosterone
3 of 32
Negative feedback...
from oestrogen (switch to positive just before LH surge). Negative feedback from tesosterone in males
4 of 32
Kallman's
failure in GnRH releasing neurons to migrate= underdeveloped gonads-- use pulsatile GnRH adminsitraiton
5 of 32
GHRH
Binds somatotrophs = growth hormone
6 of 32
Where is grwoth hormone made
arcuate nucleus
7 of 32
Released every
4 hours
8 of 32
what stimualte release
hypoglycemia, stress and exercise
9 of 32
GHRH
acts on Gs receptors of somatotrophs = GH release = direct negative feedback
10 of 32
CRH
Corticotorops (Gs) = ACTH release. ACTH made from POMC cleavage
11 of 32
Triggered by
stress and hypoglycaemia
12 of 32
ACTH
causes release of glucocorticoids and mineralocorticoids from adrenal cortex
13 of 32
Negative feedback from glucorticoids occurs.
ok
14 of 32
Thyroid...
ocntians follicles in which thyroglobulin is made- released from colloid
15 of 32
The thyroid hormones...
TSH binds thyrotorph cells (Gs) = Na/I pump = more thyroglobulin made = T3 and T4 produced.
16 of 32
TSH also binds to a1 adrenoceptors on follicular cells...
regulate iodine uptake = moe T3 nad T4
17 of 32
T3 and T4- T4 needs to eb deoiodinated to T3 first. T3s bind to receptors (TRa1 and TRB1 found peripheral, TRB3 foudn in hypothalamus and pituitary)
many effects. eg. incresed lipogenesis and lipolyiss, increased metabolism of everything and more vitamin A synthesis influences BMR and more thermogenesis
18 of 32
Brown adipose tissue is affected
more expression of the mitochodnrial uncouplign protein (UCP1)
19 of 32
TRH
T3 and T4 have negative feedback effect on it
20 of 32
Graves' disease
caused by binding of autoantibodies to TSH receptor= hyperthyroidism = enlarged goitre
21 of 32
Dopamine
inhibition of release of prolactin from lactotrophs. only exmpaleo of hypothalamic inhibition of anteiorr pituatry hromone release. Stimulatono f PRL release is by a neural reflex invovlign suckling, which decreases dopamine releas.e maya also be sti
22 of 32
be stimulate dby circulating oestrogen
which increases during pregnancy
23 of 32
postieor pituitayr
ADH and OT are synthesised in cell bodies of magnocellualr esp SON and PVN .
24 of 32
blood suplly oto PP
via the iCA
25 of 32
OT receptors
mainly Gq
26 of 32
contorl of ANS
AP= parasympathetic. PH = sympathetic.
27 of 32
hypothalamus recies input form
limbic system and nucleus of tractus solitarius (NTS)
28 of 32
ouptuts
brianstem (medullary CV scenter) and autonomic to the spinal cord
29 of 32
erection
paraysmpathetic
30 of 32
emission
sympathetic
31 of 32
mictuirition
parasympathatic
32 of 32

Other cards in this set

Card 2

Front

FSH

Back

Follicle development, ovulation in ovaries, Sertoli cells (sperm production)

Card 3

Front

LH

Back

Preview of the front of card 3

Card 4

Front

Negative feedback...

Back

Preview of the front of card 4

Card 5

Front

Kallman's

Back

Preview of the front of card 5
View more cards

Comments

No comments have yet been made

Similar Medicine resources:

See all Medicine resources »See all APP resources »