Thrombrosis & Aerterial thrombosis

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  • Created by: claudsia
  • Created on: 05-01-22 12:32

Intro to Thrombrosis & Aerterial thrombosis

Haemostatis Over view

- Vessel Injury

- Vasoconstriction

- platelets roll and adhere ( bound exposed collagen by vWF and GPIB, release granules such as ADP and thromboxane A2 which

- aggregates platelets and activates them

(exposure of collagen releases TF which binds with cofactor 7. activated co factor 7 binds to TF which makes activated serine protease. Cleaves factor 10 to become activated factor 10 which binds to factor 5.

- COmplex is active and cleaves pro thrombin to make active thrombin) (extrinsic pathway)

Intrinsinc Amplification pathway is when much thrombin is made

- Thrombin cleaves fac 11, 8 and 5. activating them

Factor VIII is stabilised by vWF. activated VIII cleaves IXa which activates fac X. thrombin activates V which binds to give more V-X activated complex which cleaves prothrombin to create thrombin.

- Thrombin activates factor 11 whichadds to cycling activation of the IX pthway which binds to VIII

-          A lot of this occurs on the negatively charged platelet surface that ow attracts + coag facs from…

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