Thrombrosis & Aerterial thrombosis
- Created by: claudsia
- Created on: 05-01-22 12:32
Intro to Thrombrosis & Aerterial thrombosis
Haemostatis Over view
- Vessel Injury
- Vasoconstriction
- platelets roll and adhere ( bound exposed collagen by vWF and GPIB, release granules such as ADP and thromboxane A2 which
- aggregates platelets and activates them
(exposure of collagen releases TF which binds with cofactor 7. activated co factor 7 binds to TF which makes activated serine protease. Cleaves factor 10 to become activated factor 10 which binds to factor 5.
- COmplex is active and cleaves pro thrombin to make active thrombin) (extrinsic pathway)
Intrinsinc Amplification pathway is when much thrombin is made
- Thrombin cleaves fac 11, 8 and 5. activating them
Factor VIII is stabilised by vWF. activated VIII cleaves IXa which activates fac X. thrombin activates V which binds to give more V-X activated complex which cleaves prothrombin to create thrombin.
- Thrombin activates factor 11 whichadds to cycling activation of the IX pthway which binds to VIII
- A lot of this occurs on the negatively charged platelet surface that ow attracts + coag facs from…
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