Biological Therapies for Schizophrenia
Two types of drugs, first generation (typical) and second generation (atypical)
First generation (typical): Arrest dopamine production by inhibiting receptors. Reduce positive symptoms. Eg. Chlorpromazine
Second generation (atypical): Reduce serotonin as well as dopamine. Reduce both the positive and negative symptoms.
Liberman et al (2005) found that 74% of patients on 1st and 2nd generation antipsychotics stopped taking their medication within 18 months due to side effects.
Davis et al (1989) found that 70% of those treated with antipsychotics improved within 6 weeks compared to 25% of those treated with placebos. Suggests that they are effective, but also that placebos are effective on some patients…