Investigations into neurotransmitters can be carried out by;
• Looking at metabolites in the blood
• Neuroimaging techniques
At first it was believed that excessive dopaminergic activity in brain causes schizophrenic symptoms.
- Drugs that increase dopaminergic activity such as amphetamines result in similar symptoms to schizophrenia when took by healthy people
- Such drugs also exacerbate psychotic symptoms in schizophrenic people
-Neuroleptic drugs that block dopaminergic neurons reduce psychotic symptoms
This theory was difficult to support, as post mortems did not show…