Schizophrenia - BIOLOGICAL EXPLANATION - GENETICS

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The closer the genetic relatedness the higher the likely concordance for schizophrenia.

The risk of schizophrenia for the general population is about 1%

Gottesman and Shields

  • Parent         5.6
  • Siblings      10.1
  • Siblings with one schizophrenic parent       12.9
  • Child with two schizophrenic parents         46.3
  • Grandchildren       3.7

Schizophrenia does tend to run in families BUT nature or nurture?

Twin Studies

  • Monozygotic twins: 100% genes: 46% concordance

If schizophrenia were just a

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