Effects of Oestrogen:
Transcriptional factors move from the cytoplasm to the nucleus through nuclear pores, and have specific receptor sites that bind to specific sites on DNA.
These receptor sites can be blocked by competitive inhibitors in order to prevent the gene on the specific region of DNA being transcripted. This is one way of switching a gene off.
Oestrogen is lipid soluble and therefore can fit through the phospholipid…