Pharmacology
- Created by: lollipop111
- Created on: 02-02-18 12:47
Ligand-gated Ion channels:
· Fastest response; used in neurotransmission.
· Binding of neurotransmitter causes opening of the channel's pore to ions; the cell depolarises (excitation) or hyperpolarises (inhibition).
· Cellular response results from the change in membrane potential, or from the change in intracellular ionic concentration.
· EXAMPLES: Nicotinic superfamily, glutamate superfamily, purinergic superfamily (ATP).
G-Protein Coupled Receptors:
· These are slower than the ligand-gated receptors and allow slower neurotransmission.
· Process of signal transduction:
o The G-protein trimer is bound to GDP.
o The agonist occupied receptor binds to the G-protein and GDP is exchanged for GTP. The trimer dissociates to α (which is bound to the GTP) and βγ.
o The α and βγ subunits reach and activate or inhibit effectors.
o …
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