Introduction to Pharmacology
- Created by: Ro-Po 17
- Created on: 21-07-18 15:15
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Introduction to Pharmacology
Pharmacology = study of drug action on the body, organs, tissues or cells
Drugs usually mimic/block endogenous signalling molecules
Endogenous = originating from within an organism
What makes a good signal?
- Travel to target site
Extracellular - Move through intercellular space or bloodstream (often hydrophilic)
Intracellular - Cross membranes = small and hydrophibic - Made/altered quickly
- Switched off/ reversible
Pharmacons Used (extracellular):
- Hormones - H2O soluble, lipophilic, peptide
- Cytokines - small peptides, short range, locally acting
- Growth factors - affect growth/differentiation
- Neurotransmitters
- Pheromones - AAs, peptides, proteins and Fatty acids
Drugs are:
- Usually organic
- Frequently cyclic
- Specific/non-specific
Specific = bind to specific targets
Non-specific…
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