Induced-fit hypothesis

  • In 1958 Daniel Koshland introduced the idea of a induced-fit for enzymes which condradicted the original idea of the 'Lock and key' hypothesis.
  • The induced-fit hypothesis shows that the enzyme's active site changes slightly to accommodate the shape of the substrate.
  • It is like wearing a 'glove', it can oly fit a hand but it will change slightly to accommodate…


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