Haem Metabolism synthesis

Biosynthesis of Haem

PORPHYRINS

Haems have a poryphorin structure

•  Haems have a poryphorin structure. 
• tetrapyrrole macrocyle w side chains
• contain 4 pyrrole rings
• side chains allow for interaction and hold porphyrin into hydrophobic core
• Have a metal at center coordinated by the 4 nitrogens

--metalloporphyrins--

- chlorophyll is produced when the central metak coordinated there is magnesium.

chlorophyll is magnesium coordinating and haem is iron coordinating

• co enzyme F430  is nickel coordinating
• B Vitamin B12 is Cobal coordinating

--Haem--

Haem is required in cytochromes of electro transport chains . It is mainly the component responsible for binding oxygen in haemoglobin. Due to containing iron ion that binds O2 and porphyrin ring that binds globin molecules.

draw it.

Haemoglobin synthesis

- developing red cells in bone…