Golgi

The Golgi is a stack of membrane enclosed discs; is has two faces; the cis face (sits closest to the ER) and the trans face (sits closest to the cell membrane)

Before proteins can be transported to the Golgi from the ER they must be folded correctly. N-linked glycosylation acts as a tag for correctly folded proteins and 2 out of the 3 terminal glucose molecules will be removed from correctly folded proteins.

Calnexin identified proteins that have been incorrectly folded by a mannose residue. Some of these proteins may need to be degraded, but glucosyl transferase may try to 'fix' the protein by adding…