Fructose metabolism and effects

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Fructose is a monosaccharide, often bonded to glucose to form sucrose, a disaccharide. During digestion fructose is absorbed directly into the blood stream and transported to the liver by the GLUT2 transporter where metabolism begins.

The anaerobic metabolism of fructose is initiated by the enzyme fructokinase, initially producing fructose 1-phosphate which is split to produce DHAP and glyceraldehyde, which does not have a phosphate group so a third enzyme is required for glyceraldehyde phosphorylation to glyceraldehyde 3-phosphate. At this point fructose metabolism yields intermediates leading to glycogen, fatty acid and triglyceride synthesis.

Fructose does not


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