Carlsson et al Review

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  • Created by: India
  • Created on: 19-04-19 11:52

CARLSSON ET AL REVIEW OF STUDIES

AIM: Wanted to look at neurotransmitter functioning in different parts of the brain, and the effect this has on Schizophrenia. 

The Dopamine Hypothesis

- Too much dopamine or too many dopamine receptors in different areas of the brain can link to SZ (mesolimbic and mesocortical pathway).

- Hyperdomonergia refers to too much dopamine in the brain.

The Glutamate Hypothesis

- Carlsson also found that too little glutamate (hypo) could link to symptoms of SZ.

- Evidence to support this is the drug PCP (angel dust), which produces psychosis similar to SZ by stimulating glutamate.

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