Burkitt Lymphoma

Burkitt Lymphoma

B Cells have basophilic cytoplasm.

BL is a highly aggressive lymphoma, doubling in size every 18-24 hours

composed of monomorphic sized B cells

B Cell markers are CD19, CD20, CD22

Flow cytometry used to analyse cells

Translocation of c-Myc

present in all case of BLtranslocates from band 124 from chromsome 8 to either:

• immunoglobin heavy chain region on chromsome 14
• iG kappa light chain on chrim 2p12
• ig lambda light

Myc becomes under the influence of gene promoters which drive cells through repetitive cell cycles

 Empidemolgy…