Blood clotting and skin repair



  • Damage to blood vessel wall exposes collagen and releases clotting factors.
  • Platelets bind to collagen and release more clotting factors.
  • Temporary platelet plug formed, contributing to a clot.
  • Inactive thrombokinase in blood + clotting factors -> Active thrombokinase (enzyme).
  • Active thrombokinase and calcium ions convert prothrombin in blood to active thrombin (enzyme).
  • Active thrombin converts soluble fibrinogen (in plasma) to insoluble fibrin.


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