Biochemical Explanation for Schiz,

1. THE DOPAMINE HYPOTHESIS

• lots of dopamine (d) (in amphetamines and LSD) = schiz
• lots of d = symptoms v similar to acute schiz, positive symptoms

*RANDRUP + MUNKVAD (1996) - d in rats =schiz behaviour

--> effeccts in study, reversed using neuroleptic drugs

--> Post-mortems and PET scans - examinations of dead schiz's = increased amount of d + increased receptor…