Biochemical Explanation for Schiz,

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1. THE DOPAMINE HYPOTHESIS

  • lots of dopamine (d) (in amphetamines and LSD) = schiz
  • lots of d = symptoms v similar to acute schiz, positive symptoms

*RANDRUP + MUNKVAD (1996) - d in rats =schiz behaviour

--> effeccts in study, reversed using neuroleptic drugs

--> Post-mortems and PET scans - examinations of dead schiz's = increased amount of d + increased receptor

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