Asthma
- Created by: Former Member
- Created on: 21-10-19 11:54
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Intro
- common inflammatory disease caused by genetic and environmental factors
- Airway narrowing and excess mucus cause breathing difficulties
- symptoms: wheezing, chest tighness, shortness of breath and coughing
- mild to severe and symptoms can come and go
- can results in Asthma attacks
- Affects all ages but usually starts in childhood
- most common chronic disease in children
Causes
- exact cause unknown
- results of strong response of the immune system to an allergen in the environment e.g ragweed allergen - some people may not react and some may react strongly - genetic explanation?
- environmental factors may affect risk of asthma such as airborne allergens and virus infections in infancy when the immune system is still developing
Environmental Factors
- Exposure to cigarette smoke during pregnancy or during a child's first few years - affect lung growth and development
- Exposure to different microbes in the environment - affect development of the immune system - can either increase or protect against risk of developing Asthma
- Workplace exposures - chemical irritants, industrial dusts = occupational asthma
- Poor air quality from pollution or allergens may worsen asthma - gases from heaters or vehicles, pollen, dust etc.
Other Medical Conditions
- Allergies
- Obesity
- Respiratory infections and wheezing
Race
- African Americans and Puerto Ricans are at higher risk of asthma that other races
Gender
- In children more boys that girls, in adults more women than men
https://www.nhlbi.nih.gov/health-topics/asthma
Genetic Contribution
- predicted by clustering of asthma and allery symtoms among relatives and twin studies - ranges from 55-90% genetic contribution
https://www.ncbi.nlm.nih.gov/pubmed/30805318 - genome predictors and phenotypes
Candidate Gene Analysis
- 2017 study BA Almomani et al
- 10 candidate genes e.g STIP1, ALOX5, ABCC1 - assessing association with Asthma in a Jordanian population of Arab descent
- Case control studdy - 245…
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