AO2 of the biological explanation of depression-monoamine hypothesis

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POSITIVE

  • If the explanatin is that there are monoamine deficiencies, and drugs that replace those deficiencies work, then this is evidence for the explanation.
  • The different monoamines link to the symptoms differently and treatment reflects those differences, again supporting the evidence. E.g. anxiety, compulsions, and a lack of interest, energy or concntration can all be explained by a lack of monoamines.

NEGATIVE

  • There are drugs (opipramol) that affect depression but whose action is not related to monoamine neurotransmitters, putting the monoamine hypothesis in doubt.
  • Experients where…

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