Sodium ions actively transport out of axon via sodium-potassium pump.
Potassium ions actively transport into axon via sodium-potassium pump.
Active transport of Sodium > Active transport of Potassium. 3 Sodium ions out for every 2 potassium ions in.
This makes the inside of the axon more negative. As both ions have a positive charge, there are more ions in the surrounding tissue fluid, causing the outside to be more positive than the inside.
Sodium ions start to diffuse back in naturally as potassium ions start to diffuse out.
However, most of the gates on the channels that let sodium back in are closed whilst most of the gates on the channels that letpotassium out are open.
Axon membrane is 100 times more permeable to potassium. This increases the potential difference between the negative inside and the positive outside of the membrane.
There is an electrical gradient. As potassium ions diffuse out of the axon, this makes the outside more positive. The potassium ions are positively charged and are so attracted to the negative state inside the axon. They are repelled by the positive outsideand are prevented from moving out of the axon.
Equilibrium is established when the electrical and chemical gradients are balanced and there is no net movement of ions.
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